BIOISIS ID :: TAPSNP

TAPASIN (TAP-associated glycoprotein)

Added: 09 February 2016

Description:

Human TAPASIN and TAPBPR (TAP Binding Protein, Related) are homolog proteins. TAPASIN is a part of the classical MHC-I peptide-loading complex (PLC), but TAPBPR is not a component of the PLC. Both interact with MHC-I molecules, but the functionality is different. Results of site-directed mutagenesis of HLA-A2 and TAPBPR are consistent with a view that TAPASIN and TAPBPR share a similar mode of MHC-I binding. The coordinates model of TAPASIN is available from the complex structure of TAPASIN with ERp57 (PDB ID: 3F8U), but the crystallization of TAPBPR and its complexes is difficult. We determined the low resolution structure or “shape” of the TAPASIN and TAPBPR by SAXS studies, and compared the structural similarity and differences.

Total datasets deposited with submission: 1

Supporting archive file:

Download: BID_TAPSNP.zip

Files from original BioISIS deposit containing original dat files, models and images


Data Set:

Primary – single deposit

Description:

Batch mode experiment, collected at several concentrations. Please see publication for details

Buffer (Matrix):

PBS 20.0 °C

Source: synchrotron

Instrument: 18ID/APS (BIO-CAT)

Deposited files in dataset:

Download iofq_TAPSNP.dat
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Real-space Transform: pofr_TAPSNP.dat dmax :: 101.0

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Download pofr_TAPSNP.dat